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. 2021 Dec 16;12:797298. doi: 10.3389/fphar.2021.797298

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Copyright © 2021 Li, Xiang, Huang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuroprotective effects and possible mechanisms of myricetin in Parkinson’s disease-associated models. Myricetin produces anti-PD’s effects via suppressing 6-OHDA-induced decrease in dopamine contents and tyrosine hydroxylase expression and increase in iron-staining cells in the substantia nigra. Myricetin also has protective effects in Drosophila, MES23.5 cells, SH-SY5Y cells, and Cos-7 cells, as indicated by the concrete descriptions in this figure. Whether these effects could mediate the anti-PD effect of myricetin remain unclear.