. 2021 Dec 16;12:797298. doi: 10.3389/fphar.2021.797298

TABLE 1.

Comprehensive information about the effects of myricetin in in vivo and in vitro models cerebral ischemia.

Pharmacological effect	Object	Drug administration	Possible mechanisms	References
*Reduce neuronal apoptosis	Rat	*5, 25 mg/kg	*Suppress pro-inflammatory cytokine, MDA, and reactive oxygen species production	Sun et al. (2018)
Reduce infarct area improve neurological deficits		*i.g	*Increase GSH production and SOD and Akt activity
—		*Once daily, 7 days	*Decrease NF-κB activity
*Reduce neuronal loss and apoptosis	Rat	*10, 20 mg/kg	*Reduce MDA and reactive oxygen species production	Wu et al. (2016)
*Reduce infarct area		*i.g	*Increase Nrf2 function
*Improve neurological deficits		*2 h before and every day after MCAO	*Improve mitochondrial function
*Improve learning and memory function		—	—
Attenuate OGD-induced neuronal damage, reactive oxygen species production, and mitochondrial depolarization	SH-SY5Y cells	*10 nM	*Inhibit caspase-3 activity	Wu et al. (2016)
	SH-SY5Y cells	*3 h before ODG exposure	*Inhibit caspase-3 activity	Wu et al. (2016)
Prevent glutamate-induced nuclear fragmentation and cell death	Rat cortical neurons	*0.1, 0.3, 1, 3, 10 μM	Suppress Ca²⁺ overloading, reactive oxygen species production, and caspase-3 activation	Shimmyo et al., 2008
	Rat cortical neurons	*24 h of pretreatment along with 24 h of simultaneous treatment		Shimmyo et al., 2008
Reduce 4-AP-induced Ca²⁺ influx, neuronal depolarization, and glutamate release	Isolated nerve terminals	30 μM co-incubation	Block the N-type and P/Q-type Ca²⁺ channel	Chang et al. (2015)
*Reduce OGD/R-induced pro-inflammatory cytokine production and decrease in eNOS expression/phosphorylation/activity, BH₄/BH₂ ratio, and GSH levels	HBMECs	*10, 30, 60 μM	Activate the Akt and Nrf2 signal	Zhang et al. (2019)
	HBMECs	*Pretreatment, 24 h	Activate the Akt and Nrf2 signal	Zhang et al. (2019)