Table 1.

Corresponding relationship from LLPS to the synapse.

	Up-regulation	Down-regulation
LLPS	Condensate with nanodomain-like structure	Dispersion
PSD	Clustering of proteins	Loss of proteins
Receptor	Stabilize as nanodomain	Lateral diffusion
Synapse	Potentiation	Depression

LLPS-mediated condensation of PSD proteins with nanodomain-like structures corresponds to the clustering of PSD, stabilization of AMPAR as nanodomain, and synaptic potentiation. In contrast, the dispersion of PSD protein condensate corresponds to the loss of scaffolding proteins in the PSD, increased lateral diffusion, and synaptic depression.