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. 2021 Dec 16;12:798320. doi: 10.3389/fphar.2021.798320

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Copyright © 2021 Wang, Tan, Hou and Dou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MDSC is rapidly transformed into macrophages following recruitment to the wound. This process exerts an anti-inflammatory effect and promotes wound healing. MDSC remains in diabetic wounds and affects angiogenesis, whereas diabetes hinders the recruitment of MDSC from the wound; the existence of an imbalance ratio of PMN/M-MDSC keeps the wound in an inflammatory microenvironment hindering wound healing. Therefore, MDSC promotes wound healing, whereas excessive M-MDSC impairs wound healing.