FIGURE 3.

Activity of neural networks before and after the hypoxic challenge. The activity of the motor neuron networks is described in terms of firing rate (A), fraction of spikes in network bursts, or bursting propensity (B), and coherence index, a measure of network synchrony (C). The stippled line at 54 DIV indicates when the hypoxic challenge was carried out, and the data points presented for this day are baseline recordings pre-hypoxia. Red labels along the Culture Age axis indicates that cell media was replaced these days. Lines and shaded regions indicate median ± median absolute deviation.