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. 2021 Dec 16;14:754762. doi: 10.3389/fnmol.2021.754762

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Copyright © 2021 Yeh, Hsu, Yeh, Yang, Chang, Chiang, Tang, Tsai, Jeng and Hsieh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of sulfonylurea receptor 1 (SUR1) in CARMIL3(+) neurons. (A) CARMIL3(+) neurons (arrows) had higher SUR1 intensity than CARMIL3(−) ones (arrowheads) in the mismatch and T2(+) regions after pMCAO. On the contrary, there was a low expression of SUR1 in the neurons at the control regions. (B,C) SUR1(+) neuron densities were significantly different among the three regions (p = 0.009), and so were SUR1(+) neuron ratios [the number of SUR1(+) neurons divided by that of all neurons] (p = 0.015). Higher SUR1(+) neuron densities (B) and neuron ratios (C) were noted in the mismatch and T2(+) regions compared with the control areas (all p < 0.05). (D) CARMIL3(+) neurons had significantly higher SUR1 intensity than CARMIL3(−) neurons in the mismatch and T2(+) regions. *p < 0.05; **p < 0.01. N = 4 rats in each group. Scale bar = 10 μm.