Table 4.

Genotypes associations based on genetic models and genders.

			OR (95% CI)
Age	Gender	Gene Variant	Additive	Dominant	Rececssive	p†	p‡	p§
All	Male	rs628031	1.97 (0.50–7.71)	1.77 (0.90–3.48)	1.37 (0.37–5.06)	0.332	0.756	0.633
		rs145450955	1.03 (0.49–2.18)	1.05 (0.54–2.04)	1.12 (0.56–2.22)	0.937	0.885	0.755
		rs3088442	0.81 (0.37–1.77)	0.81 (0.40–1.66)	0.94 (0.45–1.96)	0.6	0.569	0.866
		rs2292334	3.11 (1.25–7.73)	2.91 (1.37–6.19)	2.92 (1.21–7.08)	0.014	0.006*	0.018
	Female	rs628031	0.69 (0.11–4.11)	0.83 (0.36–1.89)	1.09 (0.21–5.67)	0.679	0.658	0.917
		rs145450955	1.78 (0.70–4.51)	1.99 (0.86–4.63)	1.56 (0.63–3.84)	0.224	0.107	0.338
		rs3088442	1.57 (0.54–4.55)	1.43 (0.63–3.22)	1.22 (0.45–3.31)	0.407	0.392	0.703
		rs2292334	0.53 (0.18–1.52)	0.70 (0.31–1.61)	0.55 (0.19–1.50)	0.237	0.401	0.241
>45 years	Male	rs628031	1.45 (0.29–7.13)	1.91 (0.84–4.31)	1.07 (0.23–5.07)	0.651	0.121	0.930
		rs145450955	1.13 (0.45–2.83)	1.09 (0.49–2.48)	1.11 (0.47–2.63)	0.799	0.826	0.808
		rs3088442	1.69 (0.66–4.29)	1.82 (0.76–4.33)	1.55 (0.62–3.88)	0.273	0.178	0.353
		rs2292334	3.30 (1.09–10.1)	2.69 (1.04–6.93)	3.14 (1.04–9.47)	0.035	0.040	0.042
	Female	rs628031	NA	0.73 (0.25–2.12)	NA	NA	0.565	NA
		rs145450955	1.28 (0.43–3.86)	1.49 (0.51–4.41)	1.15 (0.39–3.45)	0.659	0.462	0.797
		rs3088442	1.25 (0.32–4.91)	1.22 (0.42–3.50)	1.19 (0.32–4.45)	0.748	0.713	0.795
		rs2292334	1.23 (0.34–4.37)	1.43 (0.48–4.19)	1.11 (0.32–3.84)	0.752	0.520	0.872

OR = odds ratio, CI = confidence interval, NA = not available.

p^†, for the additive model; p^‡, for the dominant model; and p^§, for the recessive model.

*Significant P-value, P < 0.01 after Bonferroni correction (0.05/4 for 4 variants).

^†‡§ Logistic regression analysis, adjusted for age.