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. 2021 Dec 11;13(12):evab276. doi: 10.1093/gbe/evab276

Table 1.

Matching Tumor Evolutionary Processes to Biogeographic Events and Existing Biogeographic Methods Would Provide More Insights into Cancer Cells’ Evolution and Migration

Tumor Evolutionary Processes Biogeographic Events Properties That Define Islands Biogeographic Methods
BBM BayArea DEC DIVA
Mutation (genetic divergence) Duplication n/a Yes No Yes Yes
Extinction Extinction n/a Yes Yes Yes Yes
Founder-event Founder-event effect n/a No Customize Customize Customize
Migration Expansion n/a Yes Yes Yes No
Distant dispersal n/a Yes Yes and distance-dependent effect on the dispersal probability Yes Yes
n/a Vicariance n/a No No Yes Yes
Sampling time or mutation rate Time n/a Customize Customize Customize No
n/a n/a Area size Customize No No No
n/a n/a Isolation (distance between areas) Customize No No No