Table 1.
Matching Tumor Evolutionary Processes to Biogeographic Events and Existing Biogeographic Methods Would Provide More Insights into Cancer Cells’ Evolution and Migration
| Tumor Evolutionary Processes | Biogeographic Events | Properties That Define Islands | Biogeographic Methods |
|||
|---|---|---|---|---|---|---|
| BBM | BayArea | DEC | DIVA | |||
| Mutation (genetic divergence) | Duplication | n/a | Yes | No | Yes | Yes |
| Extinction | Extinction | n/a | Yes | Yes | Yes | Yes |
| Founder-event | Founder-event effect | n/a | No | Customize | Customize | Customize |
| Migration | Expansion | n/a | Yes | Yes | Yes | No |
| Distant dispersal | n/a | Yes | Yes and distance-dependent effect on the dispersal probability | Yes | Yes | |
| n/a | Vicariance | n/a | No | No | Yes | Yes |
| Sampling time or mutation rate | Time | n/a | Customize | Customize | Customize | No |
| n/a | n/a | Area size | Customize | No | No | No |
| n/a | n/a | Isolation (distance between areas) | Customize | No | No | No |