Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
mtDNA mutations with varying percentage levels may lead to acquired CDDP resistance in cancer. The identified mtDNA mutations were found to cause the decrease of mitochondrial complex I activity and the elevation of intracellular ROS levels. ROS upregulate the expression of IAPs and phosphorylation of IкB-α and NF-кB, which led to the decreased sensitivity to CDDP. CDDP, cisplatin; mtDNA, mitochondrial DNA; ROS, reactive oxygen species; IAPs, inhibitors of apoptosis proteins.
