1 FEV1 (% predicted) |
2 |
74 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.04 [‐11.98, 1.89] |
1.1 1‐4 weeks |
2 |
74 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.04 [‐11.98, 1.89] |
1.2 1‐5 months |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
1.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
2 FEV1 (litres) |
6 |
227 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.08 [‐0.27, 0.11] |
2.1 1‐4 weeks |
4 |
150 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.06 [‐0.28, 0.16] |
2.2 1‐5 months |
2 |
77 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.13 [‐0.48, 0.23] |
2.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
3 FEV1 (% predicted, litre measures combined) |
8 |
301 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.15 [‐0.38, 0.07] |
3.1 1‐4 weeks |
6 |
224 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.15 [‐0.41, 0.11] |
3.2 1‐5 months |
2 |
77 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.16 [‐0.60, 0.29] |
3.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
4 FVC (% predicted) |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
0.60 [‐8.79, 9.99] |
4.1 1‐4 weeks |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
0.60 [‐8.79, 9.99] |
4.2 1‐5 months |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
4.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
5 FVC (litres) |
5 |
203 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.06 [‐0.29, 0.17] |
5.1 1‐4 weeks |
4 |
150 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.32, 0.22] |
5.2 1‐5 months |
1 |
53 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.08 [‐0.54, 0.38] |
5.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6 FVC (% predicted, litre measures combined) |
6 |
257 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.29, 0.20] |
6.1 1‐4 weeks |
5 |
204 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.31, 0.24] |
6.2 1‐5 months |
1 |
53 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.09 [‐0.63, 0.45] |
6.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7 Clinic PEFR (% predicted) |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.0 [‐14.55, 10.55] |
7.1 1‐4 weeks |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.0 [‐14.55, 10.55] |
7.2 1‐5 months |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8 Morning PEFR (% predicted) |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.90 [‐16.86, 11.06] |
8.1 1‐4 weeks |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.90 [‐16.86, 11.06] |
8.2 1‐5 months |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9 Morning PEFR (L/min) |
6 |
220 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.99 [‐28.43, 22.45] |
9.1 1‐4 weeks |
4 |
144 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.83 [‐33.57, 29.90] |
9.2 1‐5 months |
2 |
76 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.07 [‐47.64, 37.49] |
9.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10 Morning PEFR (% predicted, L/min measures combined) |
7 |
274 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.28, 0.20] |
10.1 1‐4 weeks |
5 |
198 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.04 [‐0.32, 0.24] |
10.2 1‐5 months |
2 |
76 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.50, 0.40] |
10.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
11 Evening PEFR (L/min) |
5 |
211 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.47 [‐31.50, 20.56] |
11.1 1‐4 weeks |
3 |
126 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.74 [‐40.72, 29.25] |
11.2 1‐5 months |
2 |
85 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.14 [‐44.11, 33.82] |
11.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
12 Daytime breathlessness score |
2 |
74 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.26 [‐0.20, 0.72] |
12.1 1‐4 weeks |
1 |
42 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.27 [‐0.34, 0.88] |
12.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.25 [‐0.45, 0.94] |
12.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
13 Morning breathlessness score |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.34 [‐0.85, 0.17] |
13.1 1‐4 weeks |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.34 [‐0.85, 0.17] |
13.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
13.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
14 Daytime wheeze score |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.29 [‐0.40, 0.99] |
14.1 1‐4 weeks |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
14.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.29 [‐0.40, 0.99] |
14.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
15 Morning wheeze score |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.15 [‐0.66, 0.36] |
15.1 1‐4 weeks |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.15 [‐0.66, 0.36] |
15.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
15.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
16 Daytime cough score |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.39 [‐0.31, 1.09] |
16.1 1‐4 weeks |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
16.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.39 [‐0.31, 1.09] |
16.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17 Morning cough score |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.61, 0.40] |
17.1 1‐4 weeks |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.61, 0.40] |
17.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
17.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18 Daily asthma symptom score |
5 |
164 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.08 [‐0.22, 0.39] |
18.1 1‐4 weeks |
5 |
164 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.08 [‐0.22, 0.39] |
18.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
18.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
19 Symptoms (daytime breathlessness, morning breathlessness, daily symptom scores combined) |
7 |
256 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.06 [‐0.18, 0.31] |
19.1 1‐4 weeks |
6 |
224 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.04 [‐0.23, 0.30] |
19.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.25 [‐0.45, 0.94] |
19.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
20 Night‐time breathlessness score |
2 |
74 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.12 [‐0.34, 0.57] |
20.1 1‐4 weeks |
1 |
42 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.15 [‐0.45, 0.76] |
20.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.62, 0.76] |
20.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
21 Evening breathlessness score |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐0.86, 0.16] |
21.1 1‐4 weeks |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐0.86, 0.16] |
21.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
21.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
22 Night‐time wheeze score |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.16 [‐0.53, 0.85] |
22.1 1‐4 weeks |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
22.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.16 [‐0.53, 0.85] |
22.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
23 Evening wheeze score |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.73, 0.28] |
23.1 1‐4 weeks |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.23 [‐0.73, 0.28] |
23.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
23.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
24 Night‐time cough score |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.43 [‐0.27, 1.13] |
24.1 1‐4 weeks |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
24.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.43 [‐0.27, 1.13] |
24.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
25 Evening cough score |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.19 [‐0.70, 0.32] |
25.1 1‐4 weeks |
1 |
60 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.19 [‐0.70, 0.32] |
25.2 1‐5 months |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
25.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
26 Symptoms (night‐time breathlessness, evening breathlessness scores combined) |
3 |
134 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.09 [‐0.43, 0.25] |
26.1 1‐4 weeks |
2 |
102 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.14 [‐0.53, 0.25] |
26.2 1‐5 months |
1 |
32 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.62, 0.76] |
26.3 6 months or longer |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
27 Daytime use of rescue beta2 agonists (puffs/day) |
1 |
32 |
Mean Difference (IV, Fixed, 95% CI) |
0.48 [‐0.13, 1.09] |
27.1 1‐4 weeks |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
27.2 1‐5 months |
1 |
32 |
Mean Difference (IV, Fixed, 95% CI) |
0.48 [‐0.13, 1.09] |
27.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
28 Morning use of rescue beta2 agonists (puffs) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.64, 0.44] |
28.1 1‐4 weeks |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.64, 0.44] |
28.2 1‐5 months |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
28.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
29 Night‐time use of rescue beta2 agonists (puffs/night) |
1 |
32 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.52, 0.42] |
29.1 1‐4 weeks |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
29.2 1‐5 months |
1 |
32 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.52, 0.42] |
29.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
30 Evening use of rescue beta2 agonists (puffs) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
1.00 [‐3.65, 1.65] |
30.1 1‐4 weeks |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
1.00 [‐3.65, 1.65] |
30.2 1‐5 months |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
30.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
31 Histamine BHR (log 10 PC20 FEV1) |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
0.43 [0.05, 0.81] |
31.1 1‐4 weeks |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
31.2 1‐5 months |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
0.43 [0.05, 0.81] |
31.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
32 Morning plasma cortisol (nmol/L) |
3 |
118 |
Mean Difference (IV, Fixed, 95% CI) |
24.32 [‐15.78, 64.41] |
32.1 1‐4 weeks |
2 |
66 |
Mean Difference (IV, Fixed, 95% CI) |
22.29 [‐37.29, 81.86] |
32.2 1‐5 months |
1 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
26.0 [‐28.21, 80.21] |
32.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
33 Plasma cortisol 30 min post 250 mcg tetracosactrin (nmol/L) |
2 |
76 |
Mean Difference (IV, Fixed, 95% CI) |
26.84 [‐24.79, 78.48] |
33.1 1‐4 weeks |
1 |
24 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐254.22, 254.22] |
33.2 1‐5 months |
1 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
28.00 [‐24.74, 80.74] |
33.3 6 months or longer |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |