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. 2002 Jan 21;2002(1):CD003530. doi: 10.1002/14651858.CD003530

Comparison 4. BDP v BUD crossover design studies, no OCS: all delivery devices.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 FEV1 (% predicted) 2 74 Mean Difference (IV, Fixed, 95% CI) ‐5.04 [‐11.98, 1.89]
1.1 MDI v MDI 1 20 Mean Difference (IV, Fixed, 95% CI) ‐5.10 [‐13.35, 3.15]
1.2 MDI v MDI+spacer 1 54 Mean Difference (IV, Fixed, 95% CI) ‐4.90 [‐17.72, 7.92]
1.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
2 FEV1 (litres) 6 227 Mean Difference (IV, Fixed, 95% CI) ‐0.08 [‐0.27, 0.11]
2.1 MDI v MDI 2 48 Mean Difference (IV, Fixed, 95% CI) 0.00 [‐0.37, 0.37]
2.2 MDI v MDI+spacer 3 155 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.33, 0.13]
2.3 DPI v DPI 1 24 Mean Difference (IV, Fixed, 95% CI) ‐0.18 [‐0.93, 0.57]
3 FEV1 (% predicted, litre measures combined) 7 248 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.15 [‐0.40, 0.10]
3.1 MDI v MDI 3 68 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.14 [‐0.62, 0.34]
3.2 MDI v MDI+spacer 3 156 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.15 [‐0.47, 0.16]
3.3 DPI v DPI 1 24 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.19 [‐0.99, 0.62]
4 FVC (% predicted) 1 54 Mean Difference (IV, Fixed, 95% CI) 0.60 [‐8.79, 9.99]
4.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 MDI v MDI+spacer 1 54 Mean Difference (IV, Fixed, 95% CI) 0.60 [‐8.79, 9.99]
4.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 FVC (litres) 5 203 Mean Difference (IV, Fixed, 95% CI) ‐0.06 [‐0.29, 0.17]
5.1 MDI v MDI 2 48 Mean Difference (IV, Fixed, 95% CI) ‐0.01 [‐0.44, 0.42]
5.2 MDI v MDI+spacer 3 155 Mean Difference (IV, Fixed, 95% CI) ‐0.08 [‐0.35, 0.20]
5.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 FVC (% predicted, litre measures combined) 6 257 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.05 [‐0.29, 0.20]
6.1 MDI v MDI 2 48 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.01 [‐0.58, 0.55]
6.2 MDI v MDI+spacer 4 209 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.06 [‐0.33, 0.21]
6.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Clinic PEFR (% predicted) 1 20 Mean Difference (IV, Fixed, 95% CI) ‐2.0 [‐14.55, 10.55]
7.1 MDI v MDI 1 20 Mean Difference (IV, Fixed, 95% CI) ‐2.0 [‐14.55, 10.55]
7.2 MDI v MDI+spacer 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Morning PEFR (% predicted) 1 54 Mean Difference (IV, Fixed, 95% CI) ‐2.90 [‐16.86, 11.06]
8.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 MDI v MDI+spacer 1 54 Mean Difference (IV, Fixed, 95% CI) ‐2.90 [‐16.86, 11.06]
8.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Morning PEFR (L/min) 6 220 Mean Difference (IV, Fixed, 95% CI) ‐2.99 [‐28.43, 22.45]
9.1 MDI v MDI 2 70 Mean Difference (IV, Fixed, 95% CI) 15.70 [‐34.17, 65.58]
9.2 MDI v MDI+spacer 3 126 Mean Difference (IV, Fixed, 95% CI) ‐9.49 [‐41.54, 22.55]
9.3 DPI v DPI 1 24 Mean Difference (IV, Fixed, 95% CI) ‐10.0 [‐86.92, 66.92]
10 Morning PEFR (% predicted, L/min measures combined) 7 274 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.04 [‐0.28, 0.20]
10.1 MDI v MDI 2 70 Std. Mean Difference (IV, Fixed, 95% CI) 0.14 [‐0.33, 0.61]
10.2 MDI v MDI+spacer 4 180 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.40, 0.19]
10.3 DPI v DPI 1 24 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.90, 0.70]
11 Evening PEFR (L/min) 5 211 Mean Difference (IV, Fixed, 95% CI) ‐5.47 [‐31.50, 20.56]
11.1 MDI v MDI 1 24 Mean Difference (IV, Fixed, 95% CI) ‐8.0 [‐86.04, 70.04]
11.2 MDI v MDI+spacer 3 155 Mean Difference (IV, Fixed, 95% CI) ‐3.81 [‐33.70, 26.09]
11.3 DPI v DPI 1 32 Mean Difference (IV, Fixed, 95% CI) ‐13.00 [‐85.07, 59.07]
12 Daytime breathlessness score 2 74 Std. Mean Difference (IV, Fixed, 95% CI) 0.26 [‐0.20, 0.72]
12.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.2 MDI v MDI+spacer 1 42 Std. Mean Difference (IV, Fixed, 95% CI) 0.27 [‐0.34, 0.88]
12.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.25 [‐0.45, 0.94]
13 Morning breathlessness score 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.34 [‐0.85, 0.17]
13.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
13.2 MDI v MDI+spacer 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.34 [‐0.85, 0.17]
13.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
14 Daytime wheeze score 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.29 [‐0.40, 0.99]
14.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
14.2 MDI v MDI+spacer 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
14.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.29 [‐0.40, 0.99]
15 Morning wheeze score 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.15 [‐0.66, 0.36]
15.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
15.2 MDI v MDI+spacer 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.15 [‐0.66, 0.36]
15.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
16 Daytime cough score 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.39 [‐0.31, 1.09]
16.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
16.2 MDI v MDI+spacer 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
16.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.39 [‐0.31, 1.09]
17 Morning cough score 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.61, 0.40]
17.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
17.2 MDI v MDI+spacer 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.11 [‐0.61, 0.40]
17.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18 Daily asthma symptom score 5 164 Std. Mean Difference (IV, Fixed, 95% CI) 0.08 [‐0.22, 0.39]
18.1 MDI v MDI 3 68 Std. Mean Difference (IV, Fixed, 95% CI) 0.09 [‐0.38, 0.57]
18.2 MDI v MDI+spacer 2 96 Std. Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.33, 0.47]
18.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
19 Symptoms (daytime breathlessness, morning breathlessness, daily symptom scores combined) 7 256 Std. Mean Difference (IV, Fixed, 95% CI) 0.06 [‐0.18, 0.31]
19.1 MDI v MDI 3 68 Std. Mean Difference (IV, Fixed, 95% CI) 0.09 [‐0.38, 0.57]
19.2 MDI v MDI+spacer 3 156 Std. Mean Difference (IV, Fixed, 95% CI) 0.01 [‐0.30, 0.33]
19.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.25 [‐0.45, 0.94]
20 Night‐time breathlessness score 2 74 Std. Mean Difference (IV, Fixed, 95% CI) 0.12 [‐0.34, 0.57]
20.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
20.2 MDI v MDI+spacer 1 42 Std. Mean Difference (IV, Fixed, 95% CI) 0.15 [‐0.45, 0.76]
20.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.62, 0.76]
21 Evening breathlessness score 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.35 [‐0.86, 0.16]
21.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
21.2 MDI v MDI+spacer 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.35 [‐0.86, 0.16]
21.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
22 Night‐time wheeze score 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.16 [‐0.53, 0.85]
22.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.2 MDI v MDI+spacer 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
22.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.16 [‐0.53, 0.85]
23 Evening wheeze score 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.23 [‐0.73, 0.28]
23.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
23.2 MDI v MDI+spacer 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.23 [‐0.73, 0.28]
23.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
24 Night‐time cough score 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.43 [‐0.27, 1.13]
24.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
24.2 MDI v MDI+spacer 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
24.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.43 [‐0.27, 1.13]
25 Evening cough score 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.19 [‐0.70, 0.32]
25.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
25.2 MDI v MDI+spacer 1 60 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.19 [‐0.70, 0.32]
25.3 DPI v DPI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
26 Symptoms (night‐time breathlessness, evening breathlessness scores combined) 3 134 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.09 [‐0.43, 0.25]
26.1 MDI v MDI 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
26.2 MDI v MDI+spacer 2 102 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.14 [‐0.53, 0.25]
26.3 DPI v DPI 1 32 Std. Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.62, 0.76]
27 Daytime use of rescue beta2 agonists (puffs/day) 1 32 Mean Difference (IV, Fixed, 95% CI) 0.48 [‐0.13, 1.09]
27.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
27.2 MDI v MDI+spacer 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
27.3 DPI v DPI 1 32 Mean Difference (IV, Fixed, 95% CI) 0.48 [‐0.13, 1.09]
28 Morning use of rescue beta2 agonists (puffs) 1 60 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.64, 0.44]
28.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
28.2 MDI v MDI+spacer 1 60 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.64, 0.44]
28.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
29 Night‐time use of rescue beta2 agonists (puffs/night) 1 32 Mean Difference (IV, Fixed, 95% CI) ‐0.05 [‐0.52, 0.42]
29.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
29.2 MDI v MDI+spacer 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
29.3 DPI v DPI 1 32 Mean Difference (IV, Fixed, 95% CI) ‐0.05 [‐0.52, 0.42]
30 Evening use of rescue beta2 agonists (puffs) 1 60 Mean Difference (IV, Fixed, 95% CI) 1.00 [‐3.65, 1.65]
30.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
30.2 MDI v MDI+spacer 1 60 Mean Difference (IV, Fixed, 95% CI) 1.00 [‐3.65, 1.65]
30.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
31 Histamine BHR (log 10 PC20 FEV1) 1 20 Mean Difference (IV, Fixed, 95% CI) 0.43 [0.05, 0.81]
31.1 MDI v MDI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
31.2 MDI v MDI+spacer 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
31.3 DPI v DPI 1 20 Mean Difference (IV, Fixed, 95% CI) 0.43 [0.05, 0.81]
32 Morning plasma cortisol (nmol/L) 3 118 Mean Difference (IV, Fixed, 95% CI) 24.32 [‐15.78, 64.41]
32.1 MDI v MDI 1 24 Mean Difference (IV, Fixed, 95% CI) 46.90 [‐92.65, 186.45]
32.2 MDI v MDI+spacer 2 94 Mean Difference (IV, Fixed, 95% CI) 22.29 [‐19.57, 64.14]
32.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
33 Plasma cortisol 30 min post 250 mcg tetracosactrin (nmol/L) 2 76 Mean Difference (IV, Fixed, 95% CI) 26.84 [‐24.79, 78.48]
33.1 MDI v MDI 1 24 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐254.22, 254.22]
33.2 MDI v MDI+spacer 1 52 Mean Difference (IV, Fixed, 95% CI) 28.00 [‐24.74, 80.74]
33.3 DPI v DPI 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]