Ebden 1986.

Methods	Setting: Wales, hospital outpatient clinic Length of intervention: 6 weeks Design: crossover, no washout Randomisation: yes, method not stated Allocation concealment: unclear Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: no details Jadad score: 3
Participants	28 adults: 20M 8F Age range: 19‐72 years Inclusion criteria Patients with chronic asthma whose "attending physician considered their asthma to be poorly controlled and require further treatment" 15% reversibility in PEFR after inhaled beta2 agonist Good inhaler technique Exclusion criteria: Use of oral steroids within 2 months of the study
Interventions	BDP: 250 mcg 3puffs 2xdaily (1500 mcg/day) via MDI BUD: 200 mcg 4 puffs 2xdaily (1600 mcg/day) via MDI+ collapsible spacer
Outcomes	FEV1 FVC Morning PEFR Evening PEFR Daily beta2 agonist (puffs/day) Daytime wheeze score Morning serum cortisol Serum cortisol 30 minutes post 250mcg tetracosactrin
Notes	Reply from author but unable to clarify details of randomisation procedure or if carryover effects were excluded. Majority of patients demonstrated a significant improvement in at least one efficacy outcome compared to baseline
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear