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. 2002 Jan 21;2002(1):CD003530. doi: 10.1002/14651858.CD003530

Stiksa 1985.

Methods Setting: Sweden, hospital outpatient clinic 
 Length of intervention period: 3 weeks 
 Randomisation: yes, computer generated sequence
 Allocation concealment: yes 
 Design: crossover, no washout
 Masking: none
 Excluded: not stated
 Withdrawals: stated
 Baseline characteristics: comparable 
 Jadad score: 3
Participants 20 adults: 11M 9F
 Mean (SD) age: 56.4 (7) years 
 Inclusion criteria: 
 Asthmatics currently receiving inhaled BDP 200 mcg/d for 8 months or longer
 Exclusion criteria:
 Not stated
Interventions 1. BDP: 200 mcg 1puff 4xdaily (800 mcg/d) via MDI
2. BUD 200 mcg 2 puffs 2xdaily (800 mcg/d) via MDI+Inhalet spacer
3. BUD 200 mcg 4 puffs 1xdaily (800 mcg/d) via MDI+Inhalet spacer
Outcomes Morning PEFR
 Evening PEFR
 Daytime breathlessness score
 Night‐time breathlessness score
 Sleeping difficulty due to asthma score
 Daily beta2 agonist use
Notes Author confirmed randomisation method and use of allocation concealment
 10 patients were receiving treatment with oral prednisolone at enrolment.
 Not stated if carryover effects were tested for.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate