Stiksa 1985.
Methods | Setting: Sweden, hospital outpatient clinic Length of intervention period: 3 weeks Randomisation: yes, computer generated sequence Allocation concealment: yes Design: crossover, no washout Masking: none Excluded: not stated Withdrawals: stated Baseline characteristics: comparable Jadad score: 3 | |
Participants | 20 adults: 11M 9F Mean (SD) age: 56.4 (7) years Inclusion criteria: Asthmatics currently receiving inhaled BDP 200 mcg/d for 8 months or longer Exclusion criteria: Not stated | |
Interventions | 1. BDP: 200 mcg 1puff 4xdaily (800 mcg/d) via MDI 2. BUD 200 mcg 2 puffs 2xdaily (800 mcg/d) via MDI+Inhalet spacer 3. BUD 200 mcg 4 puffs 1xdaily (800 mcg/d) via MDI+Inhalet spacer |
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Outcomes | Morning PEFR Evening PEFR Daytime breathlessness score Night‐time breathlessness score Sleeping difficulty due to asthma score Daily beta2 agonist use | |
Notes | Author confirmed randomisation method and use of allocation concealment 10 patients were receiving treatment with oral prednisolone at enrolment. Not stated if carryover effects were tested for. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | Low risk | A ‐ Adequate |