FIGURE 1.

Measuring disease activity across the coronary vasculature with ¹⁸F-NaF CMA and the low-attenuation plaque burden with quantitative plaque analysis. Three-dimensional (3D) rendering of coronary CT angiography coregistered with PET for evaluation of ¹⁸F-NaF uptake (blue and red; left panel). The CMA is a summary measure of ¹⁸F-NaF activity across the entire coronary vasculature as it includes all counts originating from the coronary artery 3D rendering of CT angiography–based quantitative plaque analysis with orange low-attenuation plaque (LAP) and yellow calcified plaque. The low-attenuation plaque burden was defined as the LAP volume × 100%/vessel volume. LAD = left anterior descending; LCX = left circumflex; RCA = right coronary artery.