TABLE 2.
Prediction of Myocardial Infarction in Patients with Advanced Coronary Artery Disease
| Category | Variable | Area under the curve (95% CIs) | P value |
|---|---|---|---|
| Baseline clinical characteristics | Age | 0.51 (0.35–0.67) | 0.81 |
| Sex | 0.51 (0.38–0.64) | 0.84 | |
| Body-mass index | 0.58 (0.46–0.70) | 0.23 | |
| Systolic blood pressure | 0.52 (0.37–0.67) | 0.74 | |
| Past medical history | Myocardial infarction | 0.45 (0.33–0.58) | 0.48 |
| Recent acute coronary syndrome | 0.57 (0.43–0.71) | 0.33 | |
| Percutaneous coronary intervention | 0.53 (0.40–0.67) | 0.66 | |
| Coronary artery bypass graft | 0.52 (0.39–0.65) | 0.80 | |
| Cerebrovascular accident | 0.53 (0.40–0.67) | 0.60 | |
| Comorbidities | Hypertension | 0.47 (0.35–0.59) | 0.57 |
| Hyperlipidemia | 0.48 (0.35–0.60) | 0.61 | |
| Diabetes | 0.51 (0.37–0.65) | 0.29 | |
| Smoking | 0.46 (0.32–0.60) | 0.59 | |
| Peripheral vascular disease | 0.52 (0.39–0.66) | 0.80 | |
| Biomarkers | Total cholesterol (mmol/L) | 0.53 (0.38–0.68) | 0.68 |
| LDL cholesterol (mmol/L) | 0.59 (0.43–0.75) | 0.18 | |
| HDL cholesterol (mmol/L) | 0.53 (0.38–0.67) | 0.71 | |
| Triglycerides (mmol/L) | 0.57 (0.44–0.69) | 0.33 | |
| Creatinine (μmol/L) | 0.54 (0.40–0.68) | 0.54 | |
| Risk scores | SMART | 0.57 (0.43–0.70) | 0.35 |
| CT – qualitative & noncontrast | Multivessel disease | 0.55 (0.42–0.68) | 0.48 |
| Segment involvement score | 0.56 (0.41–0.71) | 0.40 | |
| Coronary calcium score | 0.51 (0.37–0.66) | 0.87 | |
| Modified Duke index | 0.61 (0.48–0.74) | 0.11 | |
| CT – quantitative | Total plaque volume | 0.53 (0.39–0.67) | 0.65 |
| Noncalcified plaque volume | 0.54 (0.40–0.68) | 0.53 | |
| Calcified plaque volume | 0.46 (0.33–0.58) | 0.48 | |
| Low-attenuation plaque volume | 0.57 (0.41–0.72) | 0.30 | |
| Total plaque burden | 0.45 (0.33–0.57) | 0.42 | |
| Noncalcified plaque burden | 0.47 (0.35–0.59) | 0.67 | |
| Calcified plaque burden | 0.41 (0.29–0.54) | 0.16 | |
| Low-attenuation plaque burden | 0.61 (0.48–0.75) | 0.071 | |
| Area stenosis | 0.48 (0.35–0.62) | 0.79 | |
| Contrast density difference | 0.56 (0.40–0.71) | 0.33 | |
| Ischemia score | 0.52 (0.38–0.65) | 0.77 | |
| 18F-NaF PET | CMA total | 0.76 (0.68–0.83) | < 0.001 |
| TBRmax | 0.72 (0.63–0.82) | < 0.001 | |
| SUVmax | 0.70 (0.59–0.81) | 0.002 |
Receiver operator curve modeling for prediction of myocardial infarction.
HDL = high-density lipoprotein; LDL = low-density lipoprotein; SMART = Secondary Manifestations of ARTerial disease risk score; SUVmax = maximum SUV; TBRmax = maximum target-to-background ratio.