Analysis of 68Ga-PSMA−, 18F-FDG+ lesions according to PSA and Gleason score. (A) Patients with 68Ga-PSMA−, 18F-FDG+ lesions had higher PSA than patients without 68Ga-PSMA−, 18F-FDG+ lesions (20.8 ± 8.3 vs. 7.5 ± 2.5 ng/mL; P = 0.04). (B) Patients with 68Ga-PSMA−, 18F-FDG+ lesions had higher Gleason score than those without 68Ga-PSMA−, 18F-FDG+ lesions (8.8 ± 0.2 vs. 7.7 ± 0.2; P < 0.001). (C) Detection rate for patients with 68Ga-PSMA−, 18F-FDG+ lesions was higher in high-PSA than low-PSA group (12.8% vs. 47.1%, respectively; P < 0.001). (D) Detection rate for patients with 68Ga-PSMA−, 18F-FDG+ lesion was higher in high–Gleason score group than low–Gleason score group (38.2% vs. 0%, respectively; P < 0.001).