11C-glutamine tumor uptake in patient with metastatic colorectal cancer. (A–C) Axial 11C-glutamine PET/CT images corresponding to left lung metastasis (A), 2 right lung metastases (B), and brain metastasis (C). Arrowheads point to lesions. Lesion-to-blood pool ratios from whole-body scan were 2.64 (A), 2.22 (B, top arrow), 2.35 (B, bottom arrow), and 1.68 (C). (D) Contrast-enhanced MRI 6.5 wk after baseline PET imaging and treatment. Lesion is indicated with arrowhead. MRI confirms presence of brain lesion seen with 11C-glutamine PET.