11C-glutamine biodistribution and tumor imaging in patient with metastatic colorectal cancer. (A and B) Whole-body PET (A) and PET/CT (B) images of 11C-glutamine showing normal-organ accumulation and several metastases. High uptake was seen in bladder, liver, and pancreas. (C and D) Axial 11C-glutamine PET/CT fusion images corresponding to liver metastasis (C) and left humeral head metastasis (D). Arrowheads point to lesions. Lesion–to–blood pool ratios from whole-body scan were 5.33 (C) and 4.02 (D). Lesion-to-liver ratio from whole-body scan was 1.66 (C). Time–activity curves (E) for aorta, liver, liver lesions, and bone metastasis.