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. 2021 Dec 11;27:335–348. doi: 10.1016/j.omtn.2021.12.013

Figure 1.

Figure 1

ALG-10000, a prototype STOPS molecule

(A) The chemical structure of ALG-10000. lnA denotes an LNA nucleotide of adenosine. ps denotes a phosphorothioate. ln(5m)C denotes an LNA 5-methylcytosine. (B) ALG-10000 can inhibit HBV infection of HepG2 cells expressing the HBV entry receptor NTCP. The schematic details the protocol used. The dose-response curve for the inhibition of extracellular HBsAg is shown in blue, while the effect on cell viability is shown in black. Each error bar represents one standard deviation of uncertainty. (C) ALG-10000 can reduce extracellular HBsAg produced by the integrated HBV genome in HepG2.2.15 cells. The dose response for inhibition of extracellular HBsAg is shown in blue, and the effect on cell viability is shown in black. Each error bar represents one standard deviation of uncertainty.