Study	Reason for exclusion
Agostini 1983	Exercise‐induced asthma
Agostini 1983b	Exercise‐induced asthma (study same trial as above, published in different journal)
Alanko 1973	Study group ‐ adults only.
Allen 1985	Study involved 11 patients but ages were not specified. Abstract only obtained so far, authors have been written to requesting more information. Their response is awaited.
Bach‐Mortensen 1987	Exercise‐induced asthma.
Bandouvakis 1981	Study group ‐adults only.
Beck 1985	Study on acute asthma only.
BenitoFernandez 2000	Study in acute asthma only.
Boner 1984	Exercise‐induced asthma.
Boner 1987	Study on chronic asthma but a single‐dose study only.
Boner 1987b	Study on chronic asthma but a single‐dose study only.
Borut 1977	Exercise‐induced asthma.
Caubet 1988	Study on chronic asthma but a single‐dose study only.
Chen 1981	Exercise‐induced asthma.
Chervinsky 1977	Study group ‐ adults only.
Clarke 1982	Study group of 12 patients. Three patients were aged 13, 17 and 18 years. The author was written to and a response was received. Unfortunately Dr Clarke died a few years ago and so no further information could be obtained.
Cook 1985	Study in acute asthma only.
Coulthard 1985	Published data obtained is in abstract form only. The authors have been contacted for more information. Their response is awaited.
Craven 2001	Study in acute asthma only.
Crimi 1986	Study in acute asthma only.
Crimi 1992	Study group ‐ adults only.
Cropp 1975	Study on chronic asthma but a single‐dose study only.
Davis 1984	Study on chronic asthma but a single‐dose study only.
DeStefano 1990	Study on chronic asthma but a single‐dose study only.
Ducharme 1998	Study in acute asthma only.
Dutt 1990	Acute study conducted over 300 minutes
Filiz 1994	Study group ‐ adults only.
Friberg 1989	Study on chronic asthma but a single‐dose study only.
Godfrey 1975	Exercise‐induced asthma.
Godfrey 1976	Exercise‐induced asthma, sama data as in Godfrey, 1975 but published in different journal.
Greenough 1993	Study on chronic asthma but a single‐dose study only.
Groggins 1981	Study on chronic asthma but a single‐dose study only.
Groot 1994	Study group ‐ adults only.
Gross 1975	Study group ‐ adults only.
Guill 1987	Study on acute asthma only.
Hemstreet 1980	Unclear if study was an RCT. Published data unclear so authors have been contacted. Their response is awaited.
Henry 1989	Study excluded as comparison of preservative‐free IB versus preservative containing IB. Study did therefore not meet inclusion criteria.
Hodges 1981	Study in "acute wheeze" only. Alsp unclear if study an RCT.
Jedrys 1994	Unclear if study a RCT. Authors have been contacted. Their response is awaited.
Kishida 1992	Study excluded as did not involve an anticholinergic drug.
Krasnowska 1994	Study less than 7 days duration
Krasnowska 2004	Study conducted in adults
Kreisman 1984	Study in acute asthma only.
Larsson 1987	Study group ‐ adults only.
Lefcoe 1982	Study group ‐ adults only.
Lenney 1986	Study on chronic asthma but a single‐dose study only. Unclear if study an RCT.
Lew 1990	Study in acute asthma only.
Li 2003	Study conducted in acute setting.
Lightbody 1978	Study in adults only.
Lin 1978	Not an RCT ‐ maintenance phase of trial was "open".
Lines 1983	Published data obtained in abstract form only. The authors were contacted for more information. A response was received from Professor Lines but no more data was onbtained.
Mannino 1996	Study group ‐ adults only.
Mazzei 1986	Study group ‐ adults only.
McNeill 1966	Exercise‐induced asthma.
Miraglia 1983	Study not explicitly described as randomised.
Muranyi 1974	Study not an RCT. Study used parenteral atropine only.
Neijens 1981	Exercise‐induced asthma.
Neild 1985	Study group ‐ adults only.
Pasterkamp 1985	Exercise‐induced asthma.
Pauwels 1995	Study less than 7 days duration.
Peters 2000	Study group ‐ adults only. Study also in acute asthma although followed for 24 hours after admission to hospital.
Poppius 1973	Exercise‐induced asthma; study group ‐ adults only.
Rachelefsky 1978	Exercise‐induced asthma.
Rayner 1987	Study in acute asthma only.
Ream 2001	Study in acute asthma only.
Rebuck 1983	Study group ‐ adults only.
Reisman 1988	Study in acute asthma only.
Russo 1986	Exercise‐induced asthma. Unclear if trial an RCT.
Sanguinetti 1986	Exercise‐induced asthma.
Schlueter 1978	Study group ‐ adults only.
Schuh 1995	Study in acute asthma only.
Sienra Monge 2000	Study in acute asthma only.
Silverman 1981	Study excluded as did not involve an anticholinergic drug.
Simone 1986	Study group ‐ adults only.
Simonsson 1979	This paper was a review of other studies which have been retrieved.
Stokes 1983	This paper was a review of other studies which have been retrieved.
Storms 1975	Study group ‐ adults only.
Storms 1986	Study group ‐ ? if in adults only. The author was contacted and a response was received. However, no further information about this could be found.
Storr 1986	Study in acute asthma only.
Sur 1990	Study group of 11 patients, 3 later excluded. Study group aged 10‐31 yrs ‐ 3 patients aged 13, 17 and 18 years. Authors contacted for data on children. Their response is awaited.
Svenonius 1988	Exercise‐induced asthma.
Tasche 1997	Study excluded as did not involve an anticholinergic drug.
Tashkin 1977	Exercise‐induced asthma.
Taytard 1987	Exercise‐induced asthma.
Thomson 1978	Study group ‐ adults only.
Tinkelman 1976	Exercise‐induced asthma.
Town 1988	Study group ‐ adults only.
Tullett 1982	Study group ‐ adults only.
Ulrik 1992	Study did not meet inclusion criteria.
Vichyanond 1990	Study on chronic asthma but a single‐dose study only.
Walker 1987	Study group ‐ adults only.
Ward 1981	Study group ‐ adults only. Study in acute asthma only.
Ward 1985	Study group ‐ adults only. Study in acute asthma only.
Watson 1988	Study in acute asthma only.
Watson 1994	Study did not assess effects of drugs on asthma.
Wilson 1984	Exercise‐induced asthma.
Wilson 1987	Study included 10 patients, aged 9 ‐ 57 years. Authors were contacted for childrens' data, their response is awaited.
Wolkove 1981	Study group ‐ adults only.
Yeung 1980	Exercise‐induced asthma.
Yung 1998	Study excluded as did not involve an anticholinergic drug.
Zaritsky 1999	Study in acute asthma only.
Zorc 1999	Study in acute asthma only.