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(A) The hub protein Med25 is a subunit of the Mediator coactivator complex. The activator interaction domain (AcID) forms a PPI network with transcriptional activators using two binding surfaces (H1 and H2) and in doing so regulates key cellular processes.19,22–25 PDB entry 2XNF was used to generate figure. (B) Schematic of the high-throughput screen to identify inhibitors of the Med25 AcID PPI network. See the Supporting Information for full screening details.
