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. 2021 Dec 6;24:87–100. doi: 10.1016/j.omto.2021.12.002

Figure 2.

Figure 2

SNX5 inhibits ccRCC cell proliferation

(A) Western blot revealed that SNX5 was efficiently overexpressed in 786-O and 769-P cells. (B) Western blot revealed that SNX5 was efficiently knocked down in 769-P and Caki-1 cells. (C) CCK8 assay demonstrated that the overexpression of SNX5 inhibited CCRCC cells proliferation. (D) CCK8 assay demonstrated that knockdown of SNX5 promoted ccRCC cells proliferation. (E) Colony formation assay showing the proliferation of the SNX5 overexpressed cells. (F) Colony formation assay showing the proliferation of the SNX5 knockdown cells. (G) In vivo growth assays showing the difference in tumor diameter and weight between SNX5 overexpressing cells and the control group. (H) In vivo growth assays showing the difference in tumor diameter and weight between SNX5 knockdown cells and the control group. (I) IHC assay showing the expression of Ki-67 and PCNA in overexpressing SNX5 ccRCC cells. (J) IHC assay showing the expression of Ki-67 and PCNA in knockdown SNX5 ccRCC cells. ∗p < 0.05; ∗∗p < 0.01.