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. 2021 Oct 11;1(12):2089–2099. doi: 10.1021/jacsau.1c00352

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© 2021 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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3D presentation of glycans affects binding. (A) Neu5Ac terminated glycans versus hemagglutinins, showing branching and sequence-length dependent binding.⁷⁰ (B) A pentameric glycosylated cholera toxin B subunit (CTxB) has a 3D match to CTxB for nM inhibition.⁷³