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. 2021 Oct 11;1(12):2089–2099. doi: 10.1021/jacsau.1c00352

Figure 6.

Figure 6

Targeting secondary binding sites in CTx. (A) Schematic of the GM1 glycan in the CTx binding site. (B) Affinity of glycans toward CTx from ITC.81 (C) Secondary binding site targeting via a click reaction proximal to the primary galactose unit and CTx inhibition.82 (D) Thiolactone ring opening to install secondary binding units and CTx/RCA120 inhibition.84