Table 1.
Characteristics of the reported cases of Glioblastoma.
| Author | Age/Sex | Time to blindness | Initial diagnosis | MRI | Treatment | Time to death after dx |
|---|---|---|---|---|---|---|
| Saebo 1949 [7] | 43/F | - | Tumor of the optic nerve | - | RT and surgical resection | One year |
| Mattson 1966 [16] | 59/ F | 1 mo | Optic neuritis | - | No treatment | 4 mo |
| Hoyt et al. 1973 [4] | 55 / M | - | - | - | RT | 9–10 mo |
| Harper and Stewart-Wynne 1978 [17] | 75 / M | - | Brain tumor | - | No treatment | 3 mo |
| 79/ F | - | Brain tumor | - | No treatment | 3 mo | |
| Spoor et al. 1980 [18] | 60 / F | 2 mo | - | - | RT | 6 mo |
| Barbaro et al. 1982 [19] | 26 / M | 2 wk | Craneopharyngioma – pituitary adenoma cyst | - | RT y CT | 8 mo |
| Evens et al. 1987 [20] | 61 / F | 1 mo | - | - | RT | 9 mo |
| Albers et al. 1988 [14] | 51/ M | 2 wk | - | T2 (Hyperintense) | No treatment | 20 mo |
| Woiciechowsky et al. 1995 [21] | 76 / M | - | Malignant optic glioma | T1 + Contrast (Enhancement) | Surgical resection and RT | - |
| Pallini et al. 1996 [22] | 59 /F | - | - | - | RT | 7 mo |
| Hahn et al. 2004 [23] | 53 /M | - | Neurosarcoidosis | T1 + contrast (Enhancement) T2 (Hyperintense) | RT and CT | - |
| Hartel et al. 2006 [24] | 59 /M | <1 mo | Unknown | - | None | 8 wk |
| Dinh et al. 2007 [3] | 48 /F | 10 wk | Tumor of the optic nerve | T1 + contrast (Enhancement) | RT | 14 mo |
| Abou - Zeid et al. 2008 [25] | 56 /M | <1 mo | Metastatic brain disease | T1 + contrast (Enhancement) | RT | 3 mo |
| Brar et al. 2009 [26] | 68 / F | 2 mo | - | T1 hypointense - isointense T1 + contrast (Enhancement) T2 (Hyperintense) | - | |
| Matloob et al. 2011 [12] | 63 / F | <1 mo | Optic neuritis | T1 + contrast (Enhancement) T2 (Hyperintense) | CT | 6 mo |
| Lincoff et al. 2012 [27] | 83 / M | <1 mo | - | T1 + contrast (Enhancement) T2 (Hyperintense) | - | - |
| Ashur- Fabian et al. 2013 [15] | 64/ M | 6 mo | - | T1 + contrast (Enhancement) | RT and CT | 54 mo |
| Colpak et al. 2014 [28] | 47 / M | <1 mo | Optic neuritis or infiltrative | T1 + contrast (Enhancement) | - | 3 mo |
| Traber et al. 2015 [5] | 65 / M | 5 wk | Tumor of the optic nerve | T1 + contrast (Enhancement) T2 (Hyperintense) | RT and CT | 4.5 mo |
| 54 / M | 7 mo | Optic neuritis | T1 + contrast (Enhancement) T2 (Hyperintense) | RT and CT | 18 mo | |
| 64 / F | 6 wk | Tumor of the optic nerve | T1 + contrast (Enhancement) T2 (Hyperintense) | RT | 6 mo | |
| 75/ M | 6 wk | Optic neuritis | T1 + contrast (Enhancement) T2 (Hyperintense) | RT | 12 mo | |
| 76 / F | 4 wk | Non-artieric ischemic optic neuritis | T1 + contrast (Enhancement) T2 (Hyperintense) | RT | 7 mo | |
| Nagaishi et al. 2015 [1] | 64 / F | - | - | T1 + contrast (Enhancement) T2 (Hyperintense) | Radiosurgery and CT | 10 mo |
| Mastorakos et al. 2017 [30] | 66/M | 12 mo | Meningioma | T1 + contrast (Enhancement) | Surgical resection and CT | 16 mo |
| Lin et al. [31] | 21/M | 4 mo | Optic neuritis | T1 + contrast (Enhancement) | Srugical resection and CT | - |
| Alabiad et al. 2020 [29] | 18/F | 4 wk | Unknown | T1 + contrast (Enhancement) | Surgical resection, CT and RT | Alive (>7 y) |
| Current case | 77/ M | 3 mo | Optic neuritis | T1 + contrast (Enhancement) T2 (Hyperintense) | None | 4 mo |
Wabbels et al. (2004) revised 45 cases, and Traber et al. (2015) reported 26 cases.