. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: Chem Biol Drug Des. 2020 Oct 2;97(3):607–627. doi: 10.1111/cbdd.13797

TABLE 2.

The sequence of grafted peptides and cell adhesion inhibition activity of peptides using two models, namely, Jurkat T cells and OVACR-3 cells and Jurkat T cells and HFLS-RA cells.

Peptide Code	Peptide Sequence	Lymphocyte Cell Adhesion Inhibition Assay IC₅₀ (μM)
Peptide Code	Peptide Sequence	Jurkat - OVCA R-3	Jurkat- HFLS- RA
SFTI-a^*	Cyclo[C¹K²A³S⁴A⁵P⁶P⁷S⁸C⁹Y¹⁰D¹¹G¹²D¹³D¹⁴]	0.043 ± 0.025	0.051 ± 0.025
SFTI-a1	Cyclo[C¹K²S³A⁴P⁵P⁶S⁷C⁸A⁹Y¹⁰D¹¹G¹²D¹³D¹⁴]	0.023 ± 0.046	0.037 ± 0.001
SFTI-a2	Cyclo[C¹K²A³S⁴A⁵P⁶P⁷S⁸C⁹(homotyrosine)¹⁰D¹¹G¹²D¹³D¹⁴]	>50	ND
SFTI-a3	Cyclo[C¹K²A³S⁴A⁵P⁶P⁷S⁸C⁹(3-Amino-3-(1-Napthyl)Propanoic Acid)¹⁰D¹¹G¹²D¹³D¹⁴]	>50	ND
SFTI-a4	Cyclo[c¹k²a³s⁴a⁵p⁶p⁷s⁸c⁹y¹⁰d¹¹g¹²d¹³d¹⁴]	>50	ND
SFTI-a5	Cyclo[d¹d²g³d⁴y⁵c⁶s⁷p⁸p⁹a¹⁰s¹¹a¹²k¹³c¹⁴]	>50	ND

Disulfide bonds are indicated by underline.

L amino acids are represented by capital letter with single letter code for amino acids. D amino acids are indicated by small letters.

Sable et al., ACS Chem. Biol. 2016 11(8):2366-2374. Amino acids are represented by single letter code