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(a) Propargyl bromide, K2CO3, acetonitrile, reflux, 12 h, 93% (6a) or 6-iodo-1-hexyne, K2CO3, acetonitrile, reflux, 12 h, 64% (6b); (b) CBr4, PPh3, CH2Cl2, 0 °C—r.t., 12 h, 94 (7a), 94% (7b); (c) K2CO3, acetonitrile dry, reflux, 12 h, 86 (4a), 82% (4b); (d) 5, CuI, DIPEA, THF, r.t, 48 h, 0.33 mmol/g loading (3a), 0.26 mmol/g loading (3b); (e) (3-azidopropyl)benzene, CuI, DIPEA, THF, r.t, 12 h, 79% (3c), 82% (3d).
