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Peptide-based DIA-TMT indicates a trend toward cell-type-dependent separation. PCA of one DIA-TKO11 analytical run at 0.5 ng total peptide input and missing value imputation. Samples are colored according to the respective TKO11 strains (i.e., WT, knockouts: met6, his4, ura2). n, number of unique peptides included in PCA.
