Table 1.
Proteins identified as interaction partners for IL-32
| ProteinAcc | Entrez ID | Organism | Full name and gene symbola |
|---|---|---|---|
| O00308 | 11060 | Homo sapiens | WW domain containing E3 ubiquitin protein ligase 2 (WWP2) |
| O14957 | 10975 | Homo sapiens | Ubiquinol-cytochrome c reductase, complex III subunit XI (UQCR11) |
| O43752 | 10228 | Homo sapiens | Syntaxin 6 (STX6) |
| O75844 | 10269 | Homo sapiens | Zinc metallopeptidase STE24 (ZMPSTE24) |
| O76094 | 6731 | Homo sapiens | Signal recognition particle 72 (SRP72) |
| P10321 | 3107 | Homo sapiens | Major histocompatibility complex, class I C (HLA-C) |
| P20645 | 4074 | Homo sapiens | Mannose-6-phosphate receptor, cation dependent (M6PR) |
| P24001 | 9235 | Homo sapiens | Interleukin 32 (IL32) |
| P30049 | 513 | Homo sapiens | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (ATP5D) |
| P30460 | 3106 | Homo sapiens | Major histocompatibility complex, class I, B (HLA-B) |
| P33908 | 4121 | Homo sapiens | Mannosidase alpha class 1A member 1 (MAN1A1) |
| P51795 | 1184 | Homo sapiens | Chloride voltage-gated channel 5 (CLCN5) |
| Q02127 | 1723 | Homo sapiens | Dihydroorotate dehydrogenase (quinone) (DHODH) |
| Q08188 | 7053 | Homo sapiens | Transglutaminase 3 (TGM3) |
| Q09470 | 3736 | Homo sapiens | Potassium voltage-gated channel subfamily A member 1 (KCNA1) |
| Q15904 | 537 | Homo sapiens | ATPase H+ transporting accessory protein 1 (ATP6AP1) |
| Q5VTU8 | 432369 | Homo sapiens | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2 (ATP5EP2) |
| Q68DH5 | 92255 | Homo sapiens | LMBR1 domain containing 2 (LMBRD2) |
| Q9BW60 | 64834 | Homo sapiens | ELOVL fatty acid elongase 1 (ELOVL1) |
| Q9BXS4 | 9528 | Homo sapiens | Transmembrane protein 59 (TMEM59) |
| Q9NP58 | 10058 | Homo sapiens | ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6) |
| Q9NPD3 | 54512 | Homo sapiens | Exosome component 4 (EXOSC4) |
| Q9NRK6 | 23456 | Homo sapiens | ATP binding cassette subfamily B member 10 (ABCB10) |
| Q9UI09 | 55967 | Homo sapiens | NADH:ubiquinone oxidoreductase subunit A12 (NDUFA12) |
| Q9Y2Q5 | 28956 | Homo sapiens | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2) |
| Q9Y5U9 | 51124 | Homo sapiens | Immediate early response 3 interacting protein 1 (IER3IP1) |
| O43861-1 | 374868 | Homo sapiens | Probable phospholipid-transporting ATPase IIB |
| P25788-1 | 5684 | Homo sapiens | Proteasome subunit alpha type-3 |
| Q08554-1 | 1823 | Homo sapiens | Desmocollin-1 |
| Q86VZ5-1 | 259230 | Homo sapiens | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
| Q93050-1 | 57130 | Homo sapiens | V-type proton ATPase 116 kDa subunit a isoform 1 |
| Q9BXP2-1 | 56996 | Homo sapiens | Solute carrier family 12 member 9 |
| Q9ULH0-1 | 57498 | Homo sapiens | Kinase D-interacting substrate of 220 kDa |
a
Proteins detected in MS-analysis of pull-down of endogenous IL-32 from hypoxic JJN-3 cells. Interaction partners were identified by excluding all MS target proteins that were not detected in all of 5 IL-32 pull-down replicates and corresponding pull-downs of IL-32 in IL-32 KO cells. Mitochondrial proteins highlighted in bold.