Table 2.

LC-MS/MS results showing downregulation of oligodendrocyte-lineage proteins are generally consistent with previously reported RNA profiles

Accession	Gene	Protein	μDIA fold-change (GFAPTg;Gfap+/R236H/wild type)	RNA-seq (GFAPTg;Gfap+/R236H/wild type)
Q64676	Ugt8	2-hydroxyacylsphingosine 1-beta-galactosyltransferase	−4.28∗∗	−1.72∗
P16330	Cnp	2′,3′-cyclic-nucleotide 3′-phosphodiesterase	−1.31∗∗	−1.55∗∗
Q61885	Mog	Myelin-oligodendrocyte glycoprotein	−1.21∗∗	−1.45
P04370	Mbp	Myelin basic protein	−1.46∗	−1.40∗
Q9D2P8	Mobp	Myelin-associated oligodendrocyte basic protein	−1.28	−1.49∗∗
P60202	Plp1	Myelin proteolipid protein	−1.33∗	−1.52
P20917	Mag	Myelin-associated glycoprotein	−1.35∗∗	−1.40∗

The average fold-change protein ratio measurements for GFAP^Tg;Gfap^+/R236H/wild-type mice shown were collected by untargeted proteomics (i.e., μDIA LC-MS/MS). Transcript measurements were taken from previously published RNA-seq data (19). Statistical analysis in both datasets is from a two-tailed t test (∗∗p < 0.01, ∗p < 0.05).