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. 2021 Dec 29;21:709. doi: 10.1186/s12935-021-02420-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — High FTH expression is linked to high risk and poor prognosis in HCC. A, B mRNA expressions of FTH1 were discovered to be overexpressed in primary hepatocellular carcinoma tissues compared to adjacent normal tissues using GEPIA and UALCAN databases. C Higher mRNA expression of FTH1 was associated with shorter OS in hepatocellular carcinoma patients (GEPIA database). D The overall survival in a cohort of 593 hepatocellular carcinoma patients was analyzed by univariate analysis. E, F The association of FTH1 expression with cancer stages and tumor grades (TCGA samples). G The level of serum ferritin in the indicated groups was determined. (Values are represented as mean ± SD. ^★P < 0.05, ^★★P < 0.01, ^★★★P < 0.001 versus indicated groups)