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. 2021 Dec 29;21:709. doi: 10.1186/s12935-021-02420-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Over-expression of FTH promotes the growth of tumor xenograft in vivo. The tumor volume A and body weight B were detected every 2 days when tumors reached 80–100 mm³. C H&E and IHC staining for FTH, PCNA and c-Caspase-3 were applied in the indicated tumor tissue. D The IHC of PCNA and FTH was scored by relative integrated optical density (IOD) value and presented as histograms. (F-G) The relative GSH and MDA levels of indicated tumor tissues were measured by commercial kits, respectively. (Values are represented as mean ± SD. ^★P < 0.05, ^★★P < 0.01 versus indicated groups)