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. 2021 Dec 29;22:914. doi: 10.1186/s12864-021-08210-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Parameters of the EpiTALE model. Parameters are represented by circles that are arranged in rows according to the bound nucleotide including 5mC. Column labels indicate the RVD, 13th AA, or combination of RVD and previous 12th AA that a parameter depends on. The outer circles are filled by a coloured circle proportional to the corresponding specificity parameters, where different colours are used for the four nucleotides and 5mC, respectively. For instance, the RVD ’HD’ has a strong preference for C, while A, 5mC and T are bound in decreasing preference, and G is a clear mismatch for ’HD’. There are no separate parameters for methylated cytosines for the sub-model at position 0, position 1 and the “conditional” sub-model, as there are no sufficient data available yet