Table 1:
Animals data and ventilation physiology
| Surfactant Additive | Saline | Bud 0.25 mg/kg | Bud 0.1 mg/kg | Bud 0.04 mg/kg |
|---|---|---|---|---|
| Protective VT ventilation | ||||
| Number in group | 6 | 6 | 6 | 5 |
| Birth weight (kg) | 3.1±0.4 | 3.1±0.3 | 2.8±0.3 | 2.9±0.4 |
| Male:Female | 3:3 | 3:3 | 1:5 | 1:4 |
| VT at 15 min (ml/kg) | 7.0±0.8 | 6.7±0.9 | 8.6±0.5 * | 7.7±0.4 |
| MAP at 15 min (cmH 2 O) | 16.0±1.2 | 16.2±1.0 | 16.1±1.0 | 17.1±1.2 |
| VT average for 6 hour | 7.6±0.4 | 7.6±0.8 | 7.6±0.8 | 7.5±0.4 |
| MAP average for 6 hour | 14.2±1.5 | 13.6±0.8 | 13.5±1.0 | 13.8±1.0 |
| VEI at 6 hour | 0.07±0.03 | 0.10±0.02 | 0.09±0.01 | 0.08±0.01 |
| OI at 6 hour | 49±52 | 20±16 | 11±7 | 36±55 |
| MAP at 6 hour (cmH 2 O) | 14.8±2.3 | 12.2±0.8 * | 12.1±0.7 * | 13.0±1.4 |
| Compliance (mL/cmH 2 O/kg) | 0.30±0.08 | 0.40±0.08 * | 0.37±0.10 | 0.40±0.05 |
| V40/kg (mL) | 27±8 | 36±8 | 47±9 * | 42±6 * |
| Injury VT for first 15 minutes | ||||
| Initial Animals in Group | 10 | 9 | 9 | 6 |
| Surviving Animals | 9 | 7 | 5 | 5 |
| Birth weight (kg) | 3.0±0.4 | 3.3±0.5 | 2.9±0.3 | 3.0±0.3 |
| Male:Female | 2:7 | 2:5 | 2:3 | 3:2 |
| VT at 15 min (ml/kg) | 7.8±1.4 | 7.9±1.3 | 8.9±1.4 | 7.9±1.2 |
| MAP at 15 min (cmH2O) | 23.8±0.0 | 23.6±0.5 | 23.8±0.1 | 23.8±0.0 |
| VT average for 6 hour | 7.7±0.8 | 8.1±0.7 | 8.1±0.6 | 7.9±0.4 |
| MAP average for 6 hour | 18.0±1.3 | 16.1±0.7t | 17.1±1.0 | 17.1±0.7 |
| VEI at 6 hour | 0.04±0.02 | 0.07±0.02t | 0.05±0.02 | 0.05±0.03 |
| OI at 6 hour | 63±48 | 53±40 | 82±62 | 74±76 |
| MAP at 6 hour (cmH2O) | 17.7±2.8 | 14.0±1.2t | 15.4±1.4 | 16.0±1.4 |
| Compliance (mL/cmH 2 O/kg) | 0.23±0.06 | 0.35±0.06t | 0.35±0.02t | 0.31±0.05t |
| V40/kg (mL) | 24±10 | 36±7t | 34±3 | 28±6 |
Mean±SD
*
p < 0.05 vs Protective VT + Saline; t p< 0.05 vs Injury VT + Saline VT= Tidal Volume, MAP=Mean Airway Pressure, VEI=Ventilation efficiency index, OI=Oxygenation index