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. Author manuscript; available in PMC: 2021 Dec 30.
Published in final edited form as: Pediatr Res. 2020 Feb 17;88(5):726–732. doi: 10.1038/s41390-020-0809-6

Table 2:

Budesonide levels in lung tissue at 6 hr.

Group Protective VT Animals Injury VT Animals
Initial Dose Free Budesonide Budesonide Esters % of initial dose † Budesonide Budesonide Esters % of initial dose †
0.25 mg/kg 750 μg 15.5±4.1μg 7.8±1.3μg 3.1±0.6% 19.1±7.6μg 7.4±14.1μg 3.5±1.7%
0.10 mg/kg 300 μg 5.9±1.6μg 0.7±1.6μg 2.2±0.6% 6.5±3.0μg 1.4±5.8μg 2.4±1.3%
0.04 mg/kg 120 μg 2.7±1.6μg 0.3±0.4μg 2.5±1.3% 3.4±0.4μg 2.7±0.μg 2.9±0.6%

Mean±SD n= 5 to 8 animals per group

†

(Free budesonide + Budesonide esters)/Initial dose given*100=% of initial dose at 6 hr.