Table 2.

Reliability of Bootstrap Estimates of Standard Deviations for ROI means of mapped Kinetics. Note approximately 700 ROIs are considered in each case, see Fig 4. Means and maxima of ROI-averaged kinetic parameters, averaged over replicates, are shown as ${\overline{\mu }}_{•}$ and ${\overline{\mu }}_{{}_{\vee }}$. Mean ROI standard deviation, averaged over replicates $({\overline{\sigma }}_{•})$, its standard error $(\overline{SE}{}_{•})$ and the overall RMSE values, computed by ROI version of (20), are reported as a percentage of the maximum $({\overline{\mu }}_{{}_{\vee }})$. Estimates ($\widehat{a}$, $\widehat{b}$, $\widehat{c}$) are based on the ROI version of (19).

Parameters	Brain FDG						Breast FLT
	Vb	Vd	Kd	Ki	MTT	Ki/K1	Vb	Vd	Kd	Ki	MTT	Ki/K1
Mean $({\overline{\mu }}_{•})$	0.04	0.60	0.26	0.01	4.56	0.04	0.27	0.26	0.04	0.01	4.24	0.14
Max $({\overline{\mu }}_{{}_{\vee }})$	0.09	1.08	0.49	0.02	8.58	0.18	1.63	1.30	0.17	0.07	8.04	0.52
${\overline{\sigma }}_{•}$	19.93	8.97	12.04	4.21	6.47	5.54	1.82	2.54	7.00	0.85	11.58	7.24
$\overline{SE}{}_{•}$	1.48	0.61	0.91	0.27	0.40	0.46	0.12	0.17	0.50	0.06	0.76	0.52
$\widehat{a}$	1.18	1.14	1.14	1.22	1.22	1.18	1.27	1.18	1.23	1.10	1.24	1.23
$\widehat{b}$	1.12	1.08	1.08	1.21	1.18	1.14	1.04	1.08	1.11	1.07	1.20	1.16
$\widehat{c}$	0.73	0.82	0.70	0.77	0.98	0.53	0.71	0.63	0.58	0.57	0.87	0.55
${\text{RMSE}}_{•}^y$	5.55	1.80	3.25	1.12	1.62	2.25	0.38	0.54	1.92	0.17	3.36	2.27
${\text{RMSE}}_{•}^z$	5.99	2.08	3.47	1.16	1.77	2.32	0.54	0.64	2.23	0.19	3.51	2.44
${\text{RMSE}}_{•}^{z_{\ast }}$	12.39	4.17	8.21	2.36	3.13	7.91	1.22	2.04	6.83	0.85	7.35	8.08