Table 2.
Analyses on the off-hour effect regarding time metrics and clinical outcomes
| Variable | Defined off-hour with arrival time (arrival mode) |
Adjusted p value | Defined off-hour with puncture time (puncture mode) |
Adjusted p value | ||
| Unadjusted ß coefficient/OR (95% CI) | Adjusted ß coefficient/OR (95% CI) * | Unadjusted ß coefficient/OR (95% CI) | Adjusted ß coefficient/OR (95% CI) † | |||
| Onset to door time | −20.91 (–39.52 to –2.30) | −21.56 (–39.96 to –3.16) | 0.022 | −3.41 (–22.43 to 15.60) | −3.20 (–22.40 to 16.00) | 0.744 |
| Door to imaging time | −0.97 (–4.86 to 2.91) | −0.82 (–4.76 to 3.12) | 0.682 | −1.51 (–5.46 to 2.44) | −1.28 (–5.27 to 2.71) | 0.529 |
| Door to puncture time | 6.06 (–7.53 to 19.65) | 6.95 (–6.70 to 20.60) | 0.318 | 4.21 (–9.63 to 18.05) | 2.26 (–11.64 to 16.16) | 0.749 |
| Puncture to reperfusion | 2.74 (–6.65 to 12.13) | 3.50 (–5.88 to 12.87) | 0.464 | −3.58 (–13.14 to 5.98) | −4.899 (–14.54 to 4.74) | 0.319 |
| Onset to puncture time | −14.85 (–35.30 to 5.60) | −14.61 (–35.12 to 5.89) | 0.162 | 0.80 (–20.06 to 21.65) | −0.94 (–21.95 to 20.07) | 0.930 |
| Onset to reperfusion time | −12.21 (–35.20 to 10.78) | −11.36 (–34.44 to 11.72) | 0.334 | −4.75 (–28.17 to 18.67) | −7.75 (–31.36 to 15.86) | 0.520 |
| Successful reperfusion | 1.01 (0.67 to 1.51) | 0.96 (0.63 to 1.46) | 0.838 | 0.99 (0.65 to 1.50) | 0.96 (0.63 to 1.47) | 0.853 |
| Symptomatic ICH | 1.08 (0.71 to 1.66) | 1.14 (0.73 to 1.76) | 0.569 | 1.18 (0.76 to 1.84) | 1.18 (0.75 to 1.85) | 0.473 |
| Asymptomatic ICH | 1.13 (0.81 to 1.57) | 1.13 (0.80 to 1.59) | 0.480 | 1.05 (0.75 to 1.47) | 1.10 (0.78 to 1.55) | 0.587 |
| Mortality in hospital | 1.09 (0.76 to 1.56) | 1.14 (0.78 to 1.67) | 0.494 | 1.13 (0.78 to 1.65) | 1.23 (0.82 to 1.86) | 0.316 |
| 90-day mRS score (shift analysis) | 0.94 (0.71 to 1.22) | 0.98 (0.74 to 1.29) | 0.881 | 0.92 (0.70 to 1.21) | 0.96 (0.72 to 1.28) | 0.792 |
| Favourable outcome | 1.01 (0.74 to 1.38) | 0.96 (0.70 to 1.33) | 0.808 | 1.04 (0.76 to 1.42) | 1.00 (0.70 to 1.42) | 0.994 |
| Mortality at 90 days | 0.96 (0.68 to 1.36) | 1.01 (0.70 to 1.46) | 0.964 | 1.01 (0.71 to 1.45) | 1.07 (0.72 to 1.59) | 0.722 |
Reference: patients who presented or get treated during the on-hour period.
*Time metrics were adjusted for gender, glucose level, intravenous thrombolysis and local anaesthesia. Other clinical outcomes were adjusted for gender, glucose level, intravenous thrombolysis, local anaesthesia, onset to door time and onset to puncture time.
†Time metrics were adjusted for diastolic blood pressure, glucose level, current smoking and baseline National Institute of Health Stroke Scale (NIHSS) score. Other clinical outcomes were adjusted for diastolic blood pressure, glucose level, current smoking, baseline NIHSS score and onset to door time.
ICH, intracranial haemorrhage; mRS, modified Rankin Scale.;