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. 2021 Jul 26;6(4):658–667. doi: 10.1136/svn-2021-001032

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Three-dimensional scanning electron microscopy analysis in three representative cases. Volume renderings assembled from serial block-face imaging highlight detailed ultrastructural organisation and characteristics of individual components for each clot (red blood cells (RBC)=yellow arrows, fibrin=red arrows, white blood cells=blue arrow). (A) Clot area with tightly packed RBC as polyhedrocytes intermixed with a limited volume of thin fibrin fibres. (B) Clot area with mixed composition consisting of both packed polyhedrocytes and dense network of thick fibrin fibres. (C) Fibrin-rich area containing dense fibrin masses with sparse polyhedrocytes.