Table 1.

Summary table

Clot component	Structure	Interacts with	Potential therapeutic agent(s)
Fibrin (factor Ia)	Fibrous protein	Platelets, factor XIII, RBCs	Alteplase, tenecteplase
Platelets	Nucleus-free cell fragments	Collagen, vWF, WBCs	GpIIb/IIIa blockers
vWF	Plasma glycoprotein	Fibrin, platelets, collagen	ADAMTS13, N-acetyle cysteine (NAC)
NET	Decondensed DNA/chromatin	Thrombin, platelets, vWF	DNase1

NET, neutrophil extracellular trap; RBC, red blood cell; vWF, von Willebrand Factor; WBC, white blood cell.