TABLE 1.
Characteristics of highly sensitized candidates, by era of listing
| Characteristic | Era 1 (n = 14 595) | Era 2 (n = 13 487) | Era 3 (n = 11 825) | P value |
|---|---|---|---|---|
| Age (y), mean (SD) | 48.4 (13.0) | 49.4 (13.0) | 49.7 (12.9) | <.001 |
| Female sex, % | 36.3 | 35.8 | 34.0 | <.001 |
| Race, % | ||||
| White | 41.2 | 38.6 | 37.5 | <.001 |
| Black | 36.3 | 36.4 | 36.1 | |
| Other | 22.4 | 25 | 26.4 | |
| Cause of ESRD, % | ||||
| Glomerular diseases | 27.8 | 28.1 | 28.4 | <.001 |
| Diabetes | 23.5 | 25.3 | 26.6 | |
| Hypertension | 24 | 22.7 | 20.9 | |
| Polycystic kidney disease | 6.5 | 6.9 | 7.1 | |
| Other | 18.2 | 17.0 | 17.0 | |
| Blood type, % | ||||
| O | 49.4 | 48.7 | 48.7 | .41 |
| A | 32.1 | 32.2 | 32.7 | |
| B | 14.8 | 15.5 | 14.6 | |
| AB | 3.7 | 3.7 | 3.9 | |
| cPRA (%), median (IQR) | 92.0 (86.0, 98.0) | 93.0 (86.0, 99.0) | 94.0 (86.0, 99.0) | <.001 |
| Estimated posttransplant survival score, mean (SD) | 49.5 (28.8) | 50.9 (29.0) | 49.7 (28.8) | <.001 |
| Years on dialysis, median (IQR) | 2.5 (0.9, 5.2) | 2.2 (0.7, 4.9) | 1.8 (0.4, 4.2) | <.001 |
| History of prior transplant | 48.3 | 47.0 | 44.0 | <.001 |
| Prior living donor transplant, % of those with a prior transplant | 36.2 | 36.2 | 39.1 | |
Abbreviations: cPRA, calculated panel reactive antibody; ESRD, end-stage renal disease; IQR, interquartile range; SD, standard deviation.