TABLE 3.

Relationships between k_w and fluid biomarkers of AD pathology

	CSF Aβ42		CSF t‐tau		CSF p‐tau
kw	Beta‐value	P‐value	Beta‐value	P‐value	Beta‐value	P‐value
Whole brain	0.51	.002	0.09	.549	–0.24	.167
Frontal lobe	0.50	.002	0.01	.999	–0.18	.287
Parietal lobe	0.56	< .001	0.12	.423	–0.29	.082
Temporal lobe	0.42	.015	0.16	.321	–0.21	.244
Precuneus	0.46	.004	0.03	.822	–0.24	.150
Medial temporal lobe	0.21	.236	0.12	.464	–0.265	.132

Abbreviations: Aβ, amyloid beta; AD, Alzheimer's disease; CSF, cerebrospinal fluid; k_w, blood‐brain barrier water exchange; p‐tau, phosphorylated tau; t‐tau, total tau.