Table 1.
Demographic, neuropsychological and global image-based parameters (Mean, Standard deviation (SD) and range)
Healthy controls – cognitively normal (HC) (N = 17) | Cognitively Impaired (MCI and AD*) N = 10) | p-value** | |||||
---|---|---|---|---|---|---|---|
Parameter | Mean | SD | Range | Mean | SD | Range | |
Age (years | 70.9 | 10.9 | 55 – 87 | 73.2 | 12.4 | 55 – 90 | 0.64 |
Sex | 6 males, 11 females | 7 males, 3 females | 0.12 | ||||
MMSE | 29.6 | 0.6 | 28 – 30 | 27.0 | 2.7 | 22 – 30 | 0.15 |
Trail-making Test B-A (TMTB-A) (sec) | 36.9 | 16.7 | 7 – 70 | 61.4 | 32.4 | 20 – 125 | 0.47 |
Logical Memory – Immediate (words) | 14.6 | 3.0 | 7 – 19 | 8.1 | 3.8 | 3 – 15 | 0.0003 |
Logical Memory – Delayed (words) | 14.1 | 2.6 | 8 – 19 | 5.0 | 2.9 | 0 – 8 | <0.0001 |
PALZ PET Score | 0.43 | 0.23 | 0.28 – 0.76 | 1.12 | 0.93 | 0.24 – 3.03 | 0.08 |
Cortical Retention Ratio (DVR) | 1.1 | 0.1 | 1.0 – 1.5 | 1.4 | 0.4 | 1.0 – 2.1 | 0.05 |
Cortical Retention Ratio (SUVR) | 1.2 | 0.2 | 1.1 – 1.8 | 1.5 | 0.4 | 1.1 – 2.5 | 0.05 |
Global Mean T1rho (sec) | 89.5 | 8.2 | 78.3 – 106.7 | 103.5 | 11.9 | 84.8 – 123.6 | 0.005 |
Global Median T1rho (sec) | 81.8 | 5.1 | 75.3 – 94.8 | 90.7 | 9.7 | 79.0 – 111.7 | 0.02 |
Cortical Volume (cc) | 456 | 71 | 340 – 583 | 411 | 62 | 332 – 496 | 0.10 |
Definitions: MMSE = Mini-Mental Status Exam (scored 0 – 30), PALZ PET Score = FDG-based score derived by Alzheimer’s Discrimination Tool (PALZ PMOD) with scores less than 1.0 considered to represent a normal FDG distribution and scores > 1.0 considered to represent an abnormal FDG distribution.
AD participants were classified as having AD based on clinical diagnoses. One of the participants (62 year old, male) had compromised memory function (logical memory, delayed = 5 words) but only moderately impaired MMSE (26). His FDG scan was normal (PET score = 0.35) and a global mean T1rho = 96.5 and global median T1 rho = 82.3. He did not undergo amyloid imaging, so his clinical AD diagnosis is questionable.
p-values: 2 sample t-test with Satterthwaite adjustment for unequal variance or Fisher’s Exact Test.