Table 1.

Demographic, neuropsychological and global image-based parameters (Mean, Standard deviation (SD) and range)

	Healthy controls – cognitively normal (HC) (N = 17)			Cognitively Impaired (MCI and AD*) N = 10)			p-value**
Parameter	Mean	SD	Range	Mean	SD	Range
Age (years	70.9	10.9	55 – 87	73.2	12.4	55 – 90	0.64
Sex	6 males, 11 females			7 males, 3 females			0.12
MMSE	29.6	0.6	28 – 30	27.0	2.7	22 – 30	0.15
Trail-making Test B-A (TMTB-A) (sec)	36.9	16.7	7 – 70	61.4	32.4	20 – 125	0.47
Logical Memory – Immediate (words)	14.6	3.0	7 – 19	8.1	3.8	3 – 15	0.0003
Logical Memory – Delayed (words)	14.1	2.6	8 – 19	5.0	2.9	0 – 8	<0.0001
PALZ PET Score	0.43	0.23	0.28 – 0.76	1.12	0.93	0.24 – 3.03	0.08
Cortical Retention Ratio (DVR)	1.1	0.1	1.0 – 1.5	1.4	0.4	1.0 – 2.1	0.05
Cortical Retention Ratio (SUVR)	1.2	0.2	1.1 – 1.8	1.5	0.4	1.1 – 2.5	0.05
Global Mean T1rho (sec)	89.5	8.2	78.3 – 106.7	103.5	11.9	84.8 – 123.6	0.005
Global Median T1rho (sec)	81.8	5.1	75.3 – 94.8	90.7	9.7	79.0 – 111.7	0.02
Cortical Volume (cc)	456	71	340 – 583	411	62	332 – 496	0.10

Definitions: MMSE = Mini-Mental Status Exam (scored 0 – 30), PALZ PET Score = FDG-based score derived by Alzheimer’s Discrimination Tool (PALZ PMOD) with scores less than 1.0 considered to represent a normal FDG distribution and scores > 1.0 considered to represent an abnormal FDG distribution.

^*AD participants were classified as having AD based on clinical diagnoses. One of the participants (62 year old, male) had compromised memory function (logical memory, delayed = 5 words) but only moderately impaired MMSE (26). His FDG scan was normal (PET score = 0.35) and a global mean T1rho = 96.5 and global median T1 rho = 82.3. He did not undergo amyloid imaging, so his clinical AD diagnosis is questionable.

^**p-values: 2 sample t-test with Satterthwaite adjustment for unequal variance or Fisher’s Exact Test.