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. Author manuscript; available in PMC: 2021 Dec 30.
Published in final edited form as: J Neuropsychiatry Clin Neurosci. 2020 Apr 14;32(4):352–361. doi: 10.1176/appi.neuropsych.19100221

Table 1.

Demographic, neuropsychological and global image-based parameters (Mean, Standard deviation (SD) and range)

Healthy controls – cognitively normal (HC) (N = 17) Cognitively Impaired (MCI and AD*) N = 10) p-value**
Parameter Mean SD Range Mean SD Range
Age (years 70.9 10.9 55 – 87 73.2 12.4 55 – 90 0.64
Sex 6 males, 11 females 7 males, 3 females 0.12
MMSE 29.6 0.6 28 – 30 27.0 2.7 22 – 30 0.15
Trail-making Test B-A (TMTB-A) (sec) 36.9 16.7 7 – 70 61.4 32.4 20 – 125 0.47
Logical Memory – Immediate (words) 14.6 3.0 7 – 19 8.1 3.8 3 – 15 0.0003
Logical Memory – Delayed (words) 14.1 2.6 8 – 19 5.0 2.9 0 – 8 <0.0001
PALZ PET Score 0.43 0.23 0.28 – 0.76 1.12 0.93 0.24 – 3.03 0.08
Cortical Retention Ratio (DVR) 1.1 0.1 1.0 – 1.5 1.4 0.4 1.0 – 2.1 0.05
Cortical Retention Ratio (SUVR) 1.2 0.2 1.1 – 1.8 1.5 0.4 1.1 – 2.5 0.05
Global Mean T1rho (sec) 89.5 8.2 78.3 – 106.7 103.5 11.9 84.8 – 123.6 0.005
Global Median T1rho (sec) 81.8 5.1 75.3 – 94.8 90.7 9.7 79.0 – 111.7 0.02
Cortical Volume (cc) 456 71 340 – 583 411 62 332 – 496 0.10

Definitions: MMSE = Mini-Mental Status Exam (scored 0 – 30), PALZ PET Score = FDG-based score derived by Alzheimer’s Discrimination Tool (PALZ PMOD) with scores less than 1.0 considered to represent a normal FDG distribution and scores > 1.0 considered to represent an abnormal FDG distribution.

*

AD participants were classified as having AD based on clinical diagnoses. One of the participants (62 year old, male) had compromised memory function (logical memory, delayed = 5 words) but only moderately impaired MMSE (26). His FDG scan was normal (PET score = 0.35) and a global mean T1rho = 96.5 and global median T1 rho = 82.3. He did not undergo amyloid imaging, so his clinical AD diagnosis is questionable.

**

p-values: 2 sample t-test with Satterthwaite adjustment for unequal variance or Fisher’s Exact Test.