Table 1.
Baseline characteristics
| High CXI (n = 173) | Intermediate CXI (n = 36) | Low CXI (n = 57) | P | |
|---|---|---|---|---|
| Age | ||||
| Median (IQR), years | 62 (49–70) | 67 (58–74.5) | 73 (64–76) | <0.001 |
| ≤40 years | 20 (11.6) | 2 (5.6) | 2 (3.5) | <0.001 |
| 41–60 years | 65 (37.6) | 10 (27.8) | 8 (14.0) | |
| 61–74 years | 67 (38.7) | 15 (41.7) | 25 (43.9) | |
| ≥75 years | 21 (12.1) | 9 (25.0) | 22 (38.6) | |
| Sex | ||||
| Male | 98 (56.7) | 19 (52.8) | 33 (57.9) | 0.951 |
| Female | 75 (43.4) | 17 (47.2) | 24 (42.1) | |
| ECOG PS | ||||
| 0–1 | 140 (80.9) | 24 (66.7) | 26 (45.6) | <0.001 |
| 2–3 | 33 (19.1) | 12 (33.3) | 31 (54.4) | |
| B‐symptoms | ||||
| Absent | 151 (87.3) | 29 (80.6) | 39 (68.4) | 0.001 |
| Present | 22 (12.7) | 7 (19.4) | 18 (31.6) | |
| Median BMI (IQR), kg/m2 | 23.4 (21.5–25.5) | 22.7 (21.4–25.1) | 22.7 (20.0–24.8) | 0.137 |
| Bulky disease | ||||
| Non‐bulky | 138 (79.8) | 31 (86.1) | 46 (80.7) | 0.739 |
| Bulky | 35 (20.2) | 5 (13.9) | 11 (19.3) | |
| Ann Arbor stage | ||||
| I–II | 86 (49.7) | 13 (36.1) | 13 (22.8) | <0.001 |
| III–IV | 87 (50.3) | 23 (63.9) | 44 (77.2) | |
| Extranodal disease | ||||
| Absent | 68 (39.3) | 14 (38.9) | 15 (26.3) | 0.098 |
| Present | 105 (60.7) | 22 (61.1) | 42 (73.7) | |
| LDH, normalized | ||||
| Normal | 88 (50.9) | 11 (30.6) | 9 (15.8) | <0.001 |
| >1 to ≤3 | 76 (43.9) | 19 (52.8) | 31 (54.4) | |
| >3 | 9 (5.2) | 6 (16.7) | 17 (29.8) | |
| NCCN‐IPI | ||||
| Low | 23 (13.3) | 1 (2.8) | 1 (1.8) | <0.001 |
| Low‐intermediate | 79 (45.7) | 10 (27.8) | 5 (8.8) | |
| High‐intermediate | 52 (30.1) | 19 (52.8) | 19 (33.3) | |
| High | 19 (11.0) | 6 (16.7) | 32 (56.1) | |
| Cell‐of‐origin (n = 174) | ||||
| GCB | 27 (24.8) | 3 (15.8) | 16 (34.8) | 0.266 |
| Non‐GCB | 82 (75.2) | 16 (84.2) | 30 (65.2) | |
Abbreviations: BMI, body mass index; CXI, cachexia index; ECOG PS, Eastern Cooperative Oncology Group performance status; GCB, germinal center B‐cell; IQR, interquartile range; LDH, lactate dehydrogenase; NCCN‐IPI, National Comprehensive Cancer Network‐International Prognostic Index.
Data are presented as number of patients (%) except median age and BMI.