Figure 2.

Principal coordinate analysis of Bray–Curtis similarity of bacterial communities showing that microbiota strongly cluster by subject. The analysis was based on the square‐root‐transformed relative abundance of zero‐radius operational taxonomic units. Four faecal samples were collected for each patient, at Months 0 and 4 of the glycine supplementation and Months 0 and 4 of the branched‐chain amino acid (BCAA) supplementation. As the overall microbiota similarity did not differ significantly between time points and supplementation, we omitted this legend on the figure for more clarity. The open symbols correspond to the samples of patients in the glycine–BCAA group and the filled symbols to the samples of patients in the BCAA–glycine group.