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. 2021 Dec 16;12:783108. doi: 10.3389/fphar.2021.783108

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Copyright © 2021 Tian, Liu, Chai, Wu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of brevinin-2MP on lipopolysaccharide (LPS)-induced production of nitrite and cytokines. ( A ) The binding of brevinin-2MP to RAW 264.7 cells. FITC-labeled brevinin-2MP (2.5, 5, and 10 μM) were incubated with RAW 264.7 cells for 15 min at 37°C before flow cytometry analysis was carried out. ( B ) Effect of brevinin-2MP on the viability of RAW 264.7 cells. ( C–F ) Effect of brevinin-2MP on the production of NO, IL-6, TNF-α, and MCP-1 in RAW 264.7 cells induced by LPS. Data are mean ± SEM (n = 4). ∗p < 0.05, ∗∗p < 0.01 and p < 0.001 indicate significant difference compared with the control that was incubated with 100 ng/mL LPS. ^### p < 0.001 indicates significant difference in comparison with the control without LPS and brevinin-2MP.