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. 2021 Oct 3;12(6):1925–1939. doi: 10.1002/jcsm.12794

Figure 5.

Figure 5

Mitochondrial oxidative stress is crucial for mitochondrial dysfunction in acute IR. (A) Western blot analysis for the expression of autophagy and mitophagy related markers in gastrocnemius tissues from CD, HFD‐S, and HFD‐L mice. (B) Western blot analysis of autophagy‐related markers in gastrocnemius muscles from vehicle DMSO or mdivi‐1 administrated HFD‐S mice. (C) qRT‐PCR analysis for ATF5 expression in gastrocnemius muscles from CD, HFD‐S, and HFD‐L mice (n = 8). (D) Western blot analysis of UPRmt targets in gastrocnemius muscles. (E) qRT‐PCR analysis for ATF5 expression in gastrocnemius muscles from vehicle DMSO or mdivi‐1 administrated HFD‐S mice (n = 5). (F) Western blot analysis of UPRmt targets in gastrocnemius muscles. (G) Western blot analysis of 4‐HNE in gastrocnemius muscles from CD, HFD‐S, and HFD‐L mice. (H) Western blot analysis of 4‐HNE in gastrocnemius muscles from vehicle or mdivi‐1 treated mice.