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. 2021 Oct 26;12(6):2174–2186. doi: 10.1002/jcsm.12827

Figure 1.

Figure 1

Expression of miR‐322/miR‐503 is inversely related to postnatal skeletal muscle growth. (A) Whole‐mount β‐gal staining of embryonic organs at E17.5. (B) The level of miR‐322/miR‐503 expression is high at birth (0 day) and 5 days in both tongue and hindlimb muscles. It drops at 14 days and sustains a low level afterward. (C) Four weeks' mandatory treadmill training led to hypertrophy of hindlimb muscles (n = 5 vs. 6). (D) Treadmill training resulted in down‐regulation of miR‐322, miR‐503, and miR‐542 in TA muscles (n = 5 vs. 6). (E) Forty‐eight hour starvation caused drops in hindlimb muscle mass (n = 5 vs. 5). (F) Starvation resulted in up‐regulation of miR‐322 and miR‐542 (n = 5 vs. 5). For all panels, * P < 0.05, ** P < 0.01, and *** P < 0.001.