TABLE 1.
G4 ligand-induced changes in melting temperature for PQSs in the presence of 10 μM NMM or PDS.
PQS | Tm in Tris (°C) | With NMM |
With PDS |
||
Tm (°C) | ΔTm (°C) | Tm (°C) | ΔTm (°C) | ||
PQS-104 | 44.9 | 49.0 | 4.1 | 50.6 | 5.7 |
PQS-157 | 68.2 | 72.4 | 4.2 | 82.1 | 13.9 |
PQS-235 | 48.7 | 58.4 | 9.7 | 55.2 | 6.5 |
PQS-255 | 49.3 | 56.2 | 6.9 | 56.6 | 7.3 |