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. Author manuscript; available in PMC: 2021 Dec 30.
Published in final edited form as: J Proteome Res. 2020 Dec 8;20(1):858–866. doi: 10.1021/acs.jproteome.0c00666

Figure 4.

Figure 4.

Tumor cell and tumor bulk proteomes. (A) Comparison of the BONCAT-ANL and BONCAT-Met samples. Selected proteins critical for pancreatic tumorigenesis are labeled. (B) Comparison of the bulk proteomes from ANL and Met total tumor lysates. (C) Comparison of BONCAT-ANL proteome and the corresponding Bulk-ANL proteome differentiates tumor cell-specific proteins from those of non-tumor cells within the TME. Tumor-specific marker proteins, including KRAS and KI67, are highlighted in the plot. Numbers on the top right and left corners (658 and 1815) indicate the sum of proteins identified as tumor cell- and TME-specific, respectively. (D) Selected GO terms enriched in the tumor cell or TME proteomes.