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. 2021 Apr 27;13:17590914211010647. doi: 10.1177/17590914211010647

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — PAN Inhibited Neuronal Ferroptosis In Vivo. Mice were induced by collagenase VII-S and treated with three concentrations of PAN. Then, (A) The neurological severity score was evaluated in the mice. (B) Corner turning was tested in the mice. (C) The forelimb placing score of the mice was assessed. (D) The MDA level was tested by a Lipid Peroxidation Assay Kit. (E) The Fe²⁺ content was detected by an Iron Assay Kit. (F) The expression of HOTAIR in mice was assessed by qRT-PCR. (G) The mRNA expression of ACSL4, SLC7A11 and GPX4 in mice was detected by qRT-PCR. ^*P<0.05, ^**P<0.01, ^***P<0.001. (n = 3 in every group). One-way analysis of variance (ANOVA) and Student’s t-test were performed to analyse the data.